Introduction

Mebatic is a fixed dose combination of Ofloxacin, a second generation fluoroquinolone 2-1antibiotic and Ornidazole a 5-nitro imidazole derivative available in 100 ml solution for infusion. Each Mebatic (ready to use) 100 ml single dose container is a clear, slightly greenish colored sterile, non pyrogenic, isotonic buffered solution containing 200 mg of Ofloxaicn and 500mg of Ornidazole. The product has a pH of 3.5-6.

Ofloxacin

Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone. Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.

Ornidazole

Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Chemically, ornidazole is 1-Chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol. It is a 5 nitroimidazole derivative. Its antimicrobial actions are similar to metronidazole and is used similarly in the treatment of susceptible protozoal infections and prophylaxis of anaerobic bacterial infections . Its antimicrobial activity is due to the reduction of the nitro group to a more reactive amine that attacks microbial DNA, inhibiting further synthesis and causing degradation of existing helical DNA structure and strand leading to protein synthesis inhibition and cell death.